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IMI
Workshop

W15--Microbial Ecology of CF Airway Infection

Friday, September 27, 2024
7:45 AM – 9:45 AM ET
Location:156 A-C

Recorded Session

    Chair(s)

  • Sage Dunham, PhD

    UC Irvine

  • Ajai Dandekar

    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Microbiology
    University of Washington

In this session, participants will explore topics related to the complexity of microbial ecology in cystic fibrosis (CF) airways. The microbial population and the health of people with CF is directly impacted by the local physiochemical environment, interactions between microbes, and interactions between microbes and host cells. These interactions are spatially heterogeneous and dynamic, shifting with changes in airway health, exposure to novel microbes, or treatment with elexacaftor/tezacaftor/ivacaftor (ETI), antibiotics, or phage therapy.

Learning Objectives:

  • Discuss interactions between microbes in the CF airway, how these interactions occur mechanistically, and how they are influenced by local conditions (e.g., oxygen availability) or external interventions such as treatment with antibiotics, phages, or ETI therapy.
  • Assess how spatial and temporal heterogeneity, microbial diversity, and community evolution influence health outcomes, such as the stability of lung function and the evolution of antibiotic resistance.
  • Explore how antibiotic, phage, or ETI therapy impact microbial populations, their evolution, and the health and wellbeing of people with CF.

Presentations:

  • 7:45 AM – 9:45 AM ET
    W15.1- Ex vivo pig lung as a new CF model for the study of Pseudomonas aeruginosa infection and phage therapy application

    Speaker: Marco Cafora, PhD (he/him/his) – University of Milan

  • 7:45 AM – 9:45 AM ET
    W15.2- Pseudomonas aeruginosa-phage interactions are influenced by polymicrobial biofilms

    Speaker: Paula Zamora, PhD (she/her/hers) – Geisel School of Medicine at Dartmouth

  • 7:45 AM – 9:45 AM ET
    W15.3- Emergence of a mucoid Staphylococcus argenteus in an individual with cystic fibrosis

    Speaker: Christine H. Rumpf, n/a (she/her/hers) – Institute of Medical Microbiology, University Hospital Muenster, Muenster, Germany

  • 7:45 AM – 9:45 AM ET
    W15.4- Within-lung Interspecies Gene Transfer Causes Rapid Evolution of Extreme Antibiotic Resistance in Cystic Fibrosis

    Speaker: Sardar Karash (he/him/his) – University of Washington

  • 7:45 AM – 9:45 AM ET
    W15.5- Airway Prevotella impair adherence of Staphylococcus aureus to respiratory tract epithelial cells

    Speaker: Maksym Goryachok, B.S (he/him/his) – University of Colorado, School of Medicine