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PTAC/CFTR
Symposium

S27--Airway Stem Cells: Tools, Targets, & Therapies

Saturday, September 28, 2024
10:15 AM – 12:15 PM ET
Location:258 A-C

Recorded Session

This session delves into the cutting-edge field of airway stem cells and their pivotal role in advancing treatments for cystic fibrosis (CF). Participants will explore a comprehensive overview of the tools, targets, and emerging therapies centered around airway stem cells, focusing on the latest research advances and promising avenues for clinical application.
We will cover key topics centered around:
1) Understanding the dynamics of airway stem cell regeneration and their impact on the restoration of functional mucociliary clearance;
2) Exploring innovative tools for studying airway stem cells;
3) Evaluating novel approaches for targeting gene correction to airway stem cells;
4) Discussing the advantages and challenges of both iPSC-derived and endogenous stem cell targeted therapeutic strategies in CF; and
5) Discussing the challenges faced in translating airway stem cell research into clinical applications for CF treatment, along with the potential opportunities for future development.
This session is designed for researchers, clinicians, and industry professionals working in the fields of regenerative medicine, respiratory biology, and cystic fibrosis therapeutics. Students and educators with an interest in stem cell biology and genetic disorders will also find this session informative and engaging
Join us for a thought-provoking exploration of airway stem cells and their transformative potential in the treatment of CF.

Learning Objectives:

  • Identify novel tools for deciphering the dynamics of airway stem cell regeneration and restoration of mucociliary transport.
  • Evaluate approaches for targeting gene correction to basal stem cells.
  • Assess the advantages and challenges of iPSC and endogenous stem cell directed therapeutic strategies for treating CF.

Presentations:

  • 10:15 AM – 12:15 PM ET
    S27.1- Lung-on-Chip Models to Understand Stem Cell Dynamics in CF

    Speaker: Amy L. Ryan, PhD – University of Iowa

  • 10:15 AM – 12:15 PM ET
    S27.2- Airway Hillocks: An Injury Resistant Stem Cell Reservoir in Mouse & Human Airways

    Speaker: Viral Shah – MGH

  • 10:15 AM – 12:15 PM ET
    S27.3- Shuttle Peptides for In Vivo Delivery of Base Editors to Epithelial Cells

    Speaker: Paul  B. McCray, Jr., MD (he/him/his) – Dept of Pediatrics/Carver College of Medicine/University of Iowa

  • 10:15 AM – 12:15 PM ET
    S27.4- Transplantation of Pluripotent Stem Cell-derived Basal Cells for Treating CF

    Speaker: Finn  J. Hawkins, MB BCh – Boston University