W12--Pathogenesis of CF Airway Infection

Thursday, September 26, 2024

10:15 AM – 12:15 PM ET

Location:206 AB

Chair(s)

Jaime Hook, MD

Icahn School of Medicine at Mount Sinai
Christine Rumpf, n/a (she/her/hers)

Institute of Medical Microbiology, University Hospital Muenster, Muenster, Germany

This workshop highlights recent advances in the understanding of host-pathogen and pathogen-pathogen interactions in the development of CF airway infection. Abstracts selected for presentation address emerging concepts in infection pathogenesis, particularly how interactions among the host, bacteria, viruses, and fungi shape pathogen persistence and virulence in the lung.

Learning Objectives:

Define how host-pathogen interactions in the CF airway promote chronic Pseudomonas infection
Identify new mechanisms by which interkingdom interactions impair pathogen clearance in the lung
Recognize how antibiotic exposure and innate immune dysfunction each contribute to airway infection pathogenesis

Presentations:

10:15 AM – 12:15 PM ET

W12.1- Oxidative stress and metabolic dysregulation promote <em>P. aeruginosa </em>biofilms during coinfections in CF
Speaker: Julianna Donohoe (she/her/hers) – Dartmouth College
10:15 AM – 12:15 PM ET

W12.2- The role of macrophage Piezo1 on bacterial clearance in Cystic Fibrosis
Speaker: Erica M. Orsini, MD (she/her/hers) – Cleveland Clinic
10:15 AM – 12:15 PM ET

W12.3- Inactivating mutations in the MexEFoprN antibiotic efflux pump of Pseudomonas aeruginosa Cystic Fibrosis clinical isolates enhance virulence
Speaker: Sheryl Fernandes (she/her/hers) – Cedars Sinai Medical Center
10:15 AM – 12:15 PM ET

W12.4- The epitranscriptomic regulation of Candida albicans infection in cystic fibrosis model.
Presenting Author: Sohail Khoshnevis, PhD (he/him/his) – Emory University School of Medicine
10:15 AM – 12:15 PM ET

W12.5- Ketogenesis enables disease tolerance during P. aeruginosa pulmonary infection
Speaker: Sebastian Riquelme – Columbia University