Icahn School of Medicine at Mount Sinai
Jaime Hook, MD is an Assistant Professor in the Departments of Medicine and Microbiology at the Icahn School of Medicine at Mount Sinai. She was a lung transplant pulmonologist at Columbia University Medical Center from 2015-2019 and now serves as a teaching attending on the Mount Sinai Hospital adult pulmonary consultation service and in the outpatient Mount Sinai Respiratory Institute. Her research program addresses the societal risk posed by pandemic viruses and drug-resistant bacteria by seeking new understanding of pathogen-induced lung injury and repair mechanisms. She uses mouse models of lung infection and real-time optical imaging of live, intact mouse and human lungs to define: (1) how influenza and its co-infecting pathogen, Staphylococcus aureus (SA) disrupt cellular, molecular, and physiological processes to cause lung alveolar damage; and (2) how influenza- and SA-damaged alveoli repair. Her group aims to develop new, host-directed approaches to therapy that circumvent pathogen drug-resistance mechanisms and are universally effective across lung infections by diverse pathogens. A recent paper from the Hook Lung Imaging Lab (PMID 37581936) reports a new role for CFTR in alveolar defense against influenza-staphylococcal coinfection.
W12--Pathogenesis of CF Airway Infection
Thursday, September 26, 2024
10:15 AM – 12:15 PM ET