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IMI

APPTT
Workshop

W01--Effect of CFTR Modulator Therapy on Infection & Inflammation in CF

Thursday, September 26, 2024
7:45 AM – 9:45 AM ET
Location:156 A-C

Recorded Session

Modulator treatment has revolutionized the care for people with cystic fibrosis improving their lifestyle and lifespan. However, the effects on infection, inflammation, and host response are not fully comprehended. This workshop will bring together I) Aspects of infection dynamics to understand the influence of modulators on the microbiome and implications for antimicrobial therapy. II) Define the effects of modulator treatment on inflammatory markers from the host and how they impact lung progression. III) Discuss real-world experiences with modulator treatment and how they translate to improve quality of life and survival.

Learning Objectives:

  • Summarize the latest research and clinical findings on infection dynamics and host responses in patients undergoing CFTR modulator therapy.
  • Elucidate the molecular mechanisms of Highly Effective Modulation Treatment on infection and inflammation, employing novel and translational methodologies.
  • Investigate the impact of CFTR modulators on immune cell functions.

Presentations:

  • 7:45 AM – 9:45 AM ET
    W01.1- Reduction in positive cultures for NTM and pulmonary disease in people with CF in the era of highly effective modulator therapy among participants in the longitudinal PREDICT study

    Speaker: Stacey L. Martiniano, MD, MSCS (she/her/hers) – Childrens Hospital Colorado and University of Colorado

  • 7:45 AM – 9:45 AM ET
    W01.2- Multi-lobe bronchoscopy reveals ETI’s effects on regional lung infection and inflammation

    Speaker: Samantha Durfey, PhD (she/her/hers) – Emory University

  • 7:45 AM – 9:45 AM ET
    W01.3- Integrative computational analysis of longitudinal effects of elexacaftor/tezacaftor/ivacaftor on sputum microbiome and proteome in patients with cystic fibrosis

    Speaker: Laura Schaupp, PhD (she/her/hers) – Charité-Universitätsmedizin Berlin

  • 7:45 AM – 9:45 AM ET
    W01.4- Effect of elexacaftor/tezacaftor/ivacaftor treatment on metabolic shift of cystic fibrosis neutrophils

    Speaker: Raul Rascon – Nationwide Children's Hospital

  • 7:45 AM – 9:45 AM ET
    W01.5- Highly Effective Modulator Therapy reprograms CF lung cell immunometabolism

    Speaker: Ying-Tsun Chen – Columbia University Irving Medical Center