Kezhi Yan, PhD

Cystic Fibrosis Foundation

Kezhi Yan, PhD is a Scientist II in the Gene Editing team at the Cystic Fibrosis Foundation Therapeutics Laboratory in Boston. He obtained his PhD in Experimental Medicine from McGill University and completed his postdoctoral training at the Dana-Farber Cancer Institute (DFCI) at Harvard Medical School, where his research focused on the application of genetic and epigenetic regulations to the discovery of new therapeutic approaches for genetic diseases. Throughout his training, he has acquired a range of research skills, particularly in extensive in vitro molecular and cell-based assays (CIRSPR gene editing, protein expression, flow cytometry, IF/ICC/IHC, and cell-based functional assays, etc.), in vivo mouse models, and genome- and epigenome-wide NGS analysis (e.g., RNA-Seq, ATAC-Seq, and ChIP-Seq). In 2022, Dr. Yan joined the Cystic Fibrosis Foundation and co-led the CFTR E2-27 super exon insertion project. He demonstrated the first proof of concept for functional rescue with an E2-27 SE, which was a major goal for the team and a significant advancement. His data was a key component of the symposium talk at NACFC 2023, and his findings have informed the decision of the high-priority Scientific Strategy by the Cystic Fibrosis Foundation.

Presentation(s):

• Optimized CFTR E2-27 super exon cargos rescue CFTR function

  Thursday, September 26, 2024
  10:15 AM – 12:15 PM ET