.jpg "Alessandra Livraghi-Butrico, PhD photo")
University of North Carolina at Chapel Hill Marsico Lung Institute
My interest in cystic fibrosis and other respiratory diseases caused by impaired mucus clearance dates back to the beginning of my scientific career. In the past two decades at UNC, I have been involved in a variety of projects aimed at understanding how failure to clear mucus impacts other components of the airway mucosal immune system. As co-director of the UNC Marsico Lung Institute/CF Center Mouse Models Core, I have been involved in a number of projects involving the phenotypic characterization of various animal models that exhibit defects in one or more of the key determinants of effective mucociliary clearance, i.e., airway hydration, mucus production, and mucin assembly. The data obtained thus far suggest that small animal models can nicely complement studies performed in vitro or in higher-order species to help us understand the basic mechanisms governing airway mucus clearance in health and disease.
TPS06.6- Development of mouse models of bronchiectasis
Saturday, September 28, 2024
8:15 AM – 9:45 AM ET