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APPTT

IMI
Symposium

S08--The Impact of Highly Effective Modulator Therapy (HEMT) on the Vicious Cycle of Obstruction, Infection, & Inflammation

Thursday, September 26, 2024
2:30 PM – 4:30 PM ET
Location:109 AB

Recorded Session

    Chair(s)

  • Deepika Polineni, MD MPH

    Washington University in St. Louis

  • Marcus Mall

    Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine
    Department of Pediatric Respiratory Medicine, Immunology and Intensive Care Medicine, Charité, Universitätsmedizin, Berlin, Germany

    • Community Chair(s)

  • TL

    Tré LaRosa

Widespread use of highly effective modulator therapy (HEMT) led to a marked improvement in CF health, and the long-term influences on the hallmark “vicious cycle” of obstruction, infection, and inflammation are under current investigation. This session will review three key areas of CF pathophysiology, i.e., muco-obstructive disease, infection, and inflammation, with emphasis on the most recent emerging evidence of the impacts of highly effective modulator therapy and contrasts with prior treatments for people with CF.

Learning Objectives:

  • Describe current knowledge of HEMT on muco-obstructive disease in CF.
  • Evaluate limitations of HEMT in addressing inflammation in CF clinical and research settings.
  • Apply current knowledge of HEMT research findings toward CF treatment decisions in infection.

Presentations:

  • 2:30 PM – 4:30 PM ET
    S08.1- Elexacaftor-tezacaftor-ivacaftor Effects in non-F508del & Unapproved CFTR Genotypes

    Speaker: Pierre-Régis Burgel, MD, PhD (he/him/his) – Assistance Publique Hopitaux de Paris and Université de Paris

  • 2:30 PM – 4:30 PM ET
    S08.2- Airway Epithelial Homeostasis & Host Defense Impacts of HEMT: New Understandings at Single Cell Level

    Speaker: Irina Lehmann, Prof (she/her/hers) – Berlin Institute of Health @ Charité University Medicine Berlin

  • 2:30 PM – 4:30 PM ET
    S08.3- What’s Old is New Again: Emerging Evidence on Mucus Obstruction, Infection & Inflammation in Children Taking HEMT

    Speaker: Felix Ratjen, MD (he/him/his) – University of Toronto

  • 2:30 PM – 4:30 PM ET
    S08.4- Long Term Data on Inflammation & Infection in Adults

    Speaker: David P. Nichols, MD – CF Foundation