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IMI

APPTT
Thematic Poster Session

TPS02--Bugs & Drugs & Immunologic Thugs

Thursday, September 26, 2024
12:30 PM – 2:00 PM ET
Location:Theater A (Exhibit & Poster Hall)

This session consists of two main parts: poster viewing followed by a moderated discussion. It is designed to engage the authors and the audience in a discussion that ties together ideas from multiple posters in the session. This session delves into the intricate dance between bacteria (the “bugs”), therapeutic interventions (the “drugs”), and the immune system (the “immunologic thugs”) in the context of cystic fibrosis. Attendees will gain insights into novel approaches for managing infections in CF, antimicrobial strategies, and host defense mechanisms. By exploring our understanding of how the immune system interacts with both bugs and drugs, attendees will learn about innovative therapies that improve outcomes for individuals living with Cystic Fibrosis in the era of CFTR modulator therapies.

Learning Objectives:

  • Describe microbial dynamics including the intricate interactions between microbial communities (bacteria, viruses, and fungi) within the lungs of individuals with CF.
  • Discuss therapeutic interventions aimed at enhancing modulator specific and non-specific treatment efficacy through regulation of the microbial and immune responses.
  • Examine the immune system’s dual role as both protector and perpetrator in CF., and how personalized interventions such as immunotherapies and anti-inflammatory agents can be used to harness the immune system’s potential in managing CF.

Presentations:

  • 12:30 PM – 2:00 PM ET
    TPS02.1- Investigation of mechanisms enabling Streptococcus spp. persistence in polymicrobial CF infections

    Speaker: Marta Rudzite, n/a (she/her/hers) – Geisel School Of Medicine at Dartmouth

  • 12:30 PM – 2:00 PM ET
    TPS02.3- Estimating the composition of the cystic fibrosis pulmonary microbiome

    Speaker: Ameer Dharamshi, MSc (he/him/his) – University of Washington

  • 12:30 PM – 2:00 PM ET
    TPS02.4- Altered Hematopoiesis and Functional Decline of Hematopoietic Stem Cells in Cystic Fibrosis Mice

    Speaker: Cassia L. Braga (she/her/hers) – Yale School of Medicine

  • 12:30 PM – 2:00 PM ET
    TPS02.5- Retarded Neutrophil Apoptosis Contributes to CF Neutrophilic Inflammation

    Speaker: Yawen Hu – LSU Health Sciences Center

  • 12:30 PM – 2:00 PM ET
    TPS02.6- Lung-resident B- and T- cell responses limit AAV6.2 redelivery to the mouse lung

    Speaker: Jay Kolls, MD – Tulane University School of Medicine

  • 12:30 PM – 2:00 PM ET
    TPS02.7- Tolerization of lymphocytes and dysregulation of low-density neutrophils are key features of PBMCs from patients with cystic fibrosis, following live Pseudomonas aeruginosa infection.

    Speaker: Jean-Michel SALLENAVE (he/him/his) – INSERM U1152, Hôpital Bichat

  • 12:30 PM – 2:00 PM ET
    TPS02.8- Single-cell RNA sequencing of circulating peripheral blood mononuclear cells from people with cystic fibrosis and  nontuberculous mycobacteria pulmonary disease.

    Speaker: Nicola I. Lore (he/him/his) – IRCCS Ospedale San Raffaele

  • 12:30 PM – 2:00 PM ET
    TPS02.9- Combined therapeutic strategies to favor the repair and regeneration of airway epithelium in cystic fibrosis despite the presence of bacterial infection

    Speaker: Damien Adam (he/him/his) – Université de Montréal / CRCHUM

  • 12:30 PM – 2:00 PM ET
    TPS02.10- Aspergillus fumigatus germination is mucus concentration dependent, affected by modulator changes to sputum, and promoted by Th2 cytokine stimulation in Cystic Fibrosis

    Speaker: T. Spencer Poore, MD, MSCS (he/him/his) – University of Alabama at Birmingham