Full Schedule

7:00 AM - 2:30 PM ET

Registration Open

7:15 AM - 8:30 AM ET

Breakfast

7:45 AM - 9:45 AM ET

W30--Polymicrobial Interactions in CF

Location: 156 A-C

Chair: – Carnegie Mellon University

Chair: – National Jewish Health

IMI

7:45 AM - 9:45 AM ET

W30.1- Widespread fungal-bacterial competition for magnesium enhances antibiotic resistance

Location: 156 A-C

Speaker: – Fred Hutchinson Cancer Center

IMI

7:45 AM - 9:45 AM ET

W30.2- Chronic Staphylococcus aureus infection alters the lung metabolome to promote co-colonization with Pseudomonas aeruginosa in the cystic fibrosis rat.

Location: 156 A-C

Speaker: – University of Alabama at Birmingham

IMI

7:45 AM - 9:45 AM ET

W30.3- Spatio-temporal association of Pseudomonas aeruginosa and Staphylococcus aureus in CF sputum during pulmonary exacerbation

Location: 156 A-C

Speaker: – The Hospital for Sick Children

IMI

7:45 AM - 9:45 AM ET

W30.4- Microenvironmental effects of a non-antibiotic therapy for a chronic airway disease modulate the virulence of its principal pathogen

Location: 156 A-C

Speaker: – Michigan State University

IMI

7:45 AM - 9:45 AM ET

W30.5- Microbial and metabolic ecology of expectorated sputum from people with cystic fibrosis from the STOP2 study

Location: 156 A-C

Speaker: – University of California Irvine

IMI

7:45 AM - 9:45 AM ET

W31--Progress Overcoming Premature Stop Codons in CFTR

Location: 157 A-C

Chair: – Departments of Biochemistry & Molecular Genetics, University of Alabama at Birmingham (UAB), Birmingham, AL

Chair: – University of Michigan

PTAC/CFTR

7:45 AM - 9:45 AM ET

W31.1- Pharmacological rescue of CFTR premature termination codon (PTC) variants

Location: 157 A-C

Speaker: – UNC-Chapel Hill

PTAC/CFTR

7:45 AM - 9:45 AM ET

W31.2- CFTR PTC readthrough can be enhanced by a transcript-specific ASO approach

Location: 157 A-C

Speaker: – Cystic Fibrosis Foundation

PTAC/CFTR

7:45 AM - 9:45 AM ET

W31.3- Rescue of CFTR nonsense mutations is enhanced under inflammatory stimuli

Location: 157 A-C

Speaker: – TIGEM- Telethon Institute of Genetics and Medicine

PTAC/CFTR

7:45 AM - 9:45 AM ET

W31.4- Determining the functional consequences of translational readthrough at common CFTR nonsense mutations

Location: 157 A-C

Speaker: – University of Rochester School of Medicine and Dentistry

PTAC/CFTR

7:45 AM - 9:45 AM ET

W31.5- Global suppression of nonsense-mediated mRNA decay exacerbates the inflammatory response

Location: 157 A-C

Speaker: – University of Colorado Anschutz Medical Campus

PTAC/CFTR

7:45 AM - 9:45 AM ET

W32--Airway Differentiation, Pathogenesis, & Repair

Location: 153 A-C

Chair: – FCUL-Faculty of Sciences, University of Lisboa

Chair: – Emory University, Atlanta, GA

Chair: – Cedars-Sinai Medical Center

APPTTPTAC/CFTR

7:45 AM - 9:45 AM ET

W32.1- Lef1 Induces Ionocyte Specification of Submucosal Gland Progenitors. Which One?

Location: 153 A-C

Speaker: – University of Iowa

APPTTPTAC/CFTR

7:45 AM - 9:45 AM ET

W32.2- Ionocytes localized in airway submucosal gland mucus tubule and ciliated ducts contribute to mucin unpacking

Location: 153 A-C

Speaker: – University of Saskatchewan

APPTTPTAC/CFTR

7:45 AM - 9:45 AM ET

W32.3- Temporal Dynamics in the Regulation of Pulmonary Ionocyte Development through NOTCH Signaling

Location: 153 A-C

Speaker: – Boston Children’s Hospital

APPTTPTAC/CFTR

7:45 AM - 9:45 AM ET

W32.4- ELD607, an Orai1 antagonist, reverses goblet cell metaplasia in βENaC mice.

Location: 153 A-C

Speaker: – Eldec Pharmaceuticals

APPTTPTAC/CFTR

7:45 AM - 9:45 AM ET

DG19--East Meets West – Complementary Therapies in CF

Location: 259 AB

Chair: – Stony Brook Medicine

Chair: – TTUHSC Department of Pediatric Pulmonology CF Center

Speaker: – Baylor College of Medicine, Christus Childrens Hospital

Speaker: – Stony Brook Medicine, Stony Brook Childrens

Speaker: – University Hospitals Cleveland Medical Center

Speaker: – Stony Brook Medicine

NRS

7:45 AM - 9:45 AM ET

DG20--Navigating ETI Mental Health Changes for Children Under 12

Location: 162 AB

Chair: – Children's Hospital of Michigan

Chair: – Michigan Medicine Department of Pediatrics, CS Mott Children's Hospital

Speaker: – Nationwide Children's Hospital

Speaker: – UNC Medical Center

Speaker: – Johns Hopkins All Children's Hospital

Speaker: – Nebraska Regional Pediatric CF Center

Speaker: – Michigan Medicine Department of Pediatrics, CS Mott Children's Hospital

Speaker: – Children's Hospital of Michigan

SW/PSYCH

7:45 AM - 9:45 AM ET

DG21--Watch Your Step!: Navigating CFTR Modulator Potholes

Location: 107 AB

Chair: – Riley Hospital for Children Indiana University Health

Chair: – UofL Health Pulmonary Specialty Clinic

Speaker: – Fairview Pharmacy Services

Speaker: – Primary Children's Cystic Fibrosis Clinic

Speaker: – Stanford Hospital

Speaker: – Texas Children's Hospital - BCM Pediatric

PHARM

7:45 AM - 9:45 AM ET

DG22--Promoting Airway Clearance: Where Are We Now?

Location: 152

Chair: – Manchester Adult Cystic Fibrosis Centre, UK

Chair: – Intermountain Health

Speaker: – Adult Cystic Fibrosis Department, Royal Brompton Hospital

Speaker: – Adult CF Center of Central Texas

Speaker: – Jacobs School of Medicine

Speaker: – Manchester Adult Cystic Fibrosis Centre, UK

Speaker: – Intermountain Health

PT&RT

7:45 AM - 9:45 AM ET

DG23--Pancreatic Prowess: Navigating CF, Liver Wellness, & Nutritional Implications

Location: 160 A-C

Chair: – Children's Healthcare of Atlanta

Chair: – University of Florida

Speaker: – UT Southwestern Medical Center

Speaker: – University of North Carolina Health

Speaker: – Nationwide Children's Hospital

Speaker: – UH Rainbow Babies and Children's Hospital / Case Western Reserve University

NTRCLIN

7:45 AM - 9:45 AM ET

DG24--Aging with Grace

Location: 252 B

Chair: – Stanford University School of Medicine

Chair: – St. Michael's Hospital, Unity Health Toronto

Speaker: – St. Michael's Hospital, Unity Health Toronto

Speaker: – Stanford University School of Medicine

Speaker: – St. Michael's Hospital, Unity Health Toronto

Speaker:

SW/PSYCH

7:45 AM - 9:45 AM ET

DG25--RC Updates & Special Topics

Location: 254 AB

Chair: – Cystic Fibrosis Foundation

Chair: – UPMC Children's Hospital of Pittsburgh

Chair:

Speaker: – UNC School of Medicine

Speaker: – University of Wisconsin - Madison

Speaker:

Speaker: – University of Colorado

CLIN

7:45 AM - 9:45 AM ET

Overview of the Current State & Needs of the U.S. CF Physician Workforce

Location: 257 AB

Chair: – University of Pittsburgh School of Medicine

Chair: – UT Health San Antonio

Speaker: – National Jewish Health

Speaker: – The University of North Carolina at Chapel Hill

Speaker: – University of Minnesota

Speaker:

Speaker: – University of North Carolina at Chapel Hill School of Medicine

Speaker: – Cystic Fibrosis Foundation

Speaker: – Children's Mercy Kansas City

Speaker: – University of Miami

Speaker: – Nationwide Children's Hospital

8:00 AM - 9:15 AM ET

CC01--Sweating it Out- What do Sweat Tests Really Tell Us?

Location: 104 AB

Chair: – Dell Children’s Medical Center of Central Texas

Chair: – University of Michigan Health

NRS

8:00 AM - 9:15 AM ET

CC01.1- When Sweat Chloride Does Not Align with Clinical Symptoms of Disease

Location: 104 AB

Speaker: – University of Utah Health Adult CF Center

8:00 AM - 9:15 AM ET

CC01.2- Unveiling a Medication Mask To Reveal a CF De-Diagnosis

Location: 104 AB

Speaker: – University of Michigan

8:00 AM - 9:15 AM ET

CC01.3- Variable Sweat Chloride Levels with Conversion from CRMS to CF

Location: 104 AB

Speaker: – University of Utah / Primary Children's Hospital

8:00 AM - 9:15 AM ET

CC01.4- Old Age, New Diagnosis?

Location: 104 AB

Speaker: – Medical University of South Carolina

8:00 AM - 9:15 AM ET

CC02--Compelling Cases: Collaboration Between Nutrition & GI

Location: 102 AB

Chair: – Indiana University Health

Chair: – Nationwide Children's Hospital

NTR

8:00 AM - 9:15 AM ET

CC02.1- Overcoming Early GI complications in CF

Location: 102 AB

Speaker: – Dartmouth Hitchcock Medical Center

8:00 AM - 9:15 AM ET

CC02.2- Low Fecal Elastase in an Obese Adult with Diabetes, IBS-C, & Normal Absorption in a Patient Newly Diagnosed with CF

Location: 102 AB

Speaker: – UW Health

8:00 AM - 9:15 AM ET

CC02.3- Managing Excessive Weight Gain Due to HEMT: Is the Answer Anti-Obesity Medications?

Location: 102 AB

Speaker: – Northwell Lenox Hill

8:00 AM - 9:15 AM ET

CC02.4- An Enzyme Odyssey: Severe Malnutrition with Essential Fatty Acid Deficiency in the Setting of Pancreatic Enzyme Intolerance in an 18-month-old Girl

Location: 102 AB

Speaker: – Children's of Alabama/University of Alabama at Birmingham

8:00 AM - 9:15 AM ET

CC03--Advanced QI

Location: 210 A-C

Chair: – Cystic Fibrosis Foundation

Chair: – Cystic Fibrosis Learning Network, John Hopkins Hospital

CLIN

8:00 AM - 9:15 AM ET

CC04--Complex Cases-Explain Yourself!

Location: 206 AB

Chair: – Health Sciences North - NEO Kids

Chair: – Primary Children's hospital

PT&RT

8:00 AM - 9:15 AM ET

CC04.1- CF + Asthma + Fungal Infection: What's a Girl to Do?

Location: 206 AB

Speaker: – London Health Sciences Centre

8:00 AM - 9:15 AM ET

CC04.2- A Troubling Teen: Managing Adherence to Airway Clearance & Exercise in the Context of Fluctuating Infections & Symptoms

Location: 206 AB

Speaker: – BC Children's Hospital

8:00 AM - 9:15 AM ET

CC04.3- What is Causing the Decline? CF or Aspergilloma?"

Location: 206 AB

Speaker: – University of Calgary Adult CF Clinic/Alberta Health Services

8:00 AM - 9:15 AM ET

CC04.4- Trial & Error in Home Airway Clearance Therapy with Rapid Onset Osteoporosis in Pediatric CF

Location: 206 AB

Speaker: – MHealth Fairview, Minneapolis, MN

8:00 AM - 9:15 AM ET

CC05--Diagnostic & Counseling Challenges

Location: 253 A-C

Chair: – Johns Hopkins University

Chair: – Department of Pediatrics, Cardinal Glennon Children's Hospital, Saint Louis University School of Medicine

CLIN

8:00 AM - 9:15 AM ET

CC05.1- True, True, & Unrelated or Just Another Diagnostic Dilemma?

Location: 253 A-C

Speaker: – Children's Mercy Kansas City

8:00 AM - 9:15 AM ET

CC05.2- Two adult siblings with CFTR variants F508del and A349V

Location: 253 A-C

Speaker: – Boston Children's and Brigham and Women's Hospitals

8:00 AM - 9:15 AM ET

CC05.3- A Case of Severe Intestinal Dysfunction: Was it CF All Along?

Location: 253 A-C

Speaker: – Providence Sacred Heart Pediatric Pulmonology Clinic

8:00 AM - 9:15 AM ET

CC05.4- When the Algorithms Don’t Quite Fit: Genetic Counseling & Diagnostic Challenges in a Healthy Three-year-old with F508del & 5T

Location: 253 A-C

Speaker: – Lenox Hill Hospital/Northwell Health

8:00 AM - 9:15 AM ET

CC06--Pregnancy in the Modern Era of CF: Questions Old and New

Location: 109 AB

Chair: – Children's National Hospital

Chair: – University of Pennsylvania Perelman School of Medicine

SW/PSYCH

8:00 AM - 9:15 AM ET

CC06.1- Redefining the Role of FEV1 in Pregnancy

Location: 109 AB

Speaker: – VCU Health System

8:00 AM - 9:15 AM ET

CC06.2- Modulator Therapy for in Utero Treatment of Fetal Meconium Ileus

Location: 109 AB

Speaker: – University Medical Center Utrecht

8:00 AM - 9:15 AM ET

CC06.3- Pre-Eclampsia and Hypertensive Disorders of Pregnancy

Location: 109 AB

Speaker: – University of Minnesota School of Medicine

8:00 AM - 9:15 AM ET

CC06.4- Balancing Risks in Pregnancy After Lung Transplant

Location: 109 AB

Speaker: – University of Pennsylvania

8:00 AM - 11:00 AM ET

Exhibit & Poster Hall Open

8:15 AM - 9:45 AM ET

TPS06--Pre-Clinical Models of CF Organ Disease