W01.1- Reduction in positive cultures for NTM and pulmonary disease in people with CF in the era of highly effective modulator therapy among participants in the longitudinal PREDICT study
W01.3- Integrative computational analysis of longitudinal effects of elexacaftor/tezacaftor/ivacaftor on sputum microbiome and proteome in patients with cystic fibrosis
TPS02.6- Lung-resident B- and T- cell responses limit AAV6.2 redelivery to the mouse lung
Location: Theater A (Exhibit & Poster Hall)
Speaker: Jay Kolls, MD – Tulane University School of Medicine
IMIAPPTT
Thursday, Sep 26th
12:30 PM – 2:00 PM ET
TPS02.7- Tolerization of lymphocytes and dysregulation of low-density neutrophils are key features of PBMCs from patients with cystic fibrosis, following live Pseudomonas aeruginosa infection.
TPS02.8- Single-cell RNA sequencing of circulating peripheral blood mononuclear cells from people with cystic fibrosis and nontuberculous mycobacteria pulmonary disease.
TPS02.9- Combined therapeutic strategies to favor the repair and regeneration of airway epithelium in cystic fibrosis despite the presence of bacterial infection
TPS02.10- Aspergillus fumigatus germination is mucus concentration dependent, affected by modulator changes to sputum, and promoted by Th2 cytokine stimulation in Cystic Fibrosis
Chair: Marcus A. Mall – Department of Pediatric Respiratory Medicine, Immunology and Intensive Care Medicine, Charité, Universitätsmedizin, Berlin, Germany
RFPT07.2- Evaluation of Pulmonary Ventilation and Perfusion in Cystic Fibrosis Lung Disease using Functional Proton and Hyperpolarized Xe Magnetic Resonance Imaging
RFPT07.3- Establishing a magnitude-independent minimum clinically important difference of hyperpolarized xenon-129 magnetic resonance ventilation imaging
RFPT07.5- Early Cystic Fibrosis Lung Disease Progression by Multiple-Breath Washout and Chest Magnetic Resonance Imaging
Location: Theater B (Exhibit & Poster Hall)
Speaker: Eva Steinke, MD (she/her/hers) – Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Germany
APPTTCLIN
Friday, Sep 27th
9:00 AM – 9:50 AM ET
RFPT07.6- Longitudinal Evaluation of the Responsiveness of Hyperpolarized 129Xe Multiple-Breath Washout MRI to Elexacaftor/Tezacaftor/Ivacaftor Treatment in Pediatric Cystic Fibrosis
RFPT07.7- Elexacaftor/tezacaftor/ivacaftor therapy improves lung clearance Index and magnetic resonance imaging scores in children with cystic fibrosis and one or two F508del alleles
W21.4- TSLP and IL-33 alarmin cytokine production by primary human CF lung macrophages is induced by infection with Pseudomonas aeruginosa and further increased by CFTR modulators.